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KMID : 0829320170200020042
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Korean Journal of Clinical Microbiology
2017 Volume.20 No. 2 p.42 ~ p.51
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Diagnostic Accuracy and Detection Rate of Real-Time PCR for Detection of Group B Streptococcal Colonization in Pregnant Women: Systemic Review of Literature and Meta-Analysis
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Park Sun-Young
Kim So-Young
Choi Won-Jung
Kim Seok-Hyun
Hong Seong-Geun
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Abstract
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Background: Group B streptococcus (Streptococcus agalactiae, GBS) was reported as a major cause of neonatal infection and death. To prevent vertical transmission, CDC recommended that all women in week 35-37 of pregnancy should receive the GBS colonization test. We conducted a systematic review and meta-analysis to evaluate diagnostic accuracy and detection rate of real-time PCR for GBS in pregnant women.
Methods: The literature review for GBS using real-time PCR was done including KoreaMed, Ovid- MEDLINE, Ovid-EMBASE, and Cochrane Library on November 3, 2015. 443 articles were collected. Two authors select articles and evaluated the quality of studies using Scottish Intercollegiate Guidelines Network tool independently.
Results: Diagnostic accuracy of the real-time PCR was assessed by meta-analysis through 34 articles (13,516 for real-time PCR, 1,815 for culture and other comparison test). The GBS colonization was assessed through 34 articles, which reported varying values of 2.0-69.2% using real-time PCR. The real-time PCR for GBS was shown to have overall sensitivity of 0.93 (95% CI 0.92-0.94, I2=86.3%), overall specificity of 0.96 (95% CI 0.96-0.96, I2= 90.2%), SROC AUC of 0.99.
Conclusion: Real-time PCR is an effective test for detecting GBS colonization in pregnant women, resulted in preventing the infection in a new born baby.
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KEYWORD
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Group B streptococcus, Pregnant women, Real-time polymerase chain reaction, Streptococcus agalactiae
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